Orders Processing,
Shipping & Receiving,
Warehouse
2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
Production Lab
Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
Nicotinic acetylcholine receptors are heteropentameric ligand-gated ion channels resulting from the assembly of alpha and beta protein subunits. This ion channel is gated by the binding of acetylcholine to the assembled receptor. Alpha 6 is often found associated with beta 3, beta 2, and alpha 4 subunits. CHRNA6 receptors have a relatively selective localization to the nigrostriatal pathway where they function to mediate dopamine release. The findings that the receptors are downregulated in response to dopaminergic nerve terminal loss and that nicotine protects against nigrostriatal damage suggests that CHRNA6 may a represent unique target for neurodegenerative disorders.
Gene Name: | cholinergic receptor, nicotinic, alpha 6 (neuronal) |
Family/Subfamily: | Ion Channel , Nicotinic acetylcholine receptor |
Synonyms: | CHRNA6, CHNRA6, AChR-alpha6, Acra6, NACHRA6, NAChR alpha 6 |
Target Sequences: | NM_004198 NP_004189.1 Q15825 |
If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.