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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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CHI3L1 / YKL‑40 Antibody (aa198‑247, HRP) LS‑C455000
YKL-40 antibody LS-C455000 is an HRP-conjugated rabbit polyclonal antibody to YKL-40 (CHI3L1) from human, rat, chimpanzee and other species. Validated for IHC and WB.
Catalog
Size
Price
LS-C455000-100
100 µl (0.65 mg/ml)
$385

Popular CHI3L1 / YKL-40 Products

Anti-YKL-40 / CHI3L1 antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 2.5-5 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Species: Human, Monkey, Rat, Rabbit
Applications: IHC, IHC - Paraffin, Western blot
Western blot of recombinant CHI3L1 / YKL-40.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Species: Mouse
Applications: IHC, Western blot
Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
Species: Human, Mouse
Applications: IHC, IHC - Paraffin, Western blot
Antibody
Species: Human
Applications: Western blot
Antibody
Species: Mouse
Applications: Western blot

Product Description

YKL-40 antibody LS-C455000 is an HRP-conjugated rabbit polyclonal antibody to YKL-40 (CHI3L1) from human, rat, chimpanzee and other species. Validated for IHC and WB.

Specifications

Target
Human CHI3L1 / YKL-40
Synonyms
CHI3L1, 39 kDa synovial protein, ASRT7, Cartilage glycoprotein 39, CGP-39, Chitinase-3-like protein 1, gp39, HCGP-39, HCGP-3P, GP-39, HC-gp39, YKL40, YYL-40, YKL-40
Host
Rabbit
Reactivity
Human, Chimpanzee, Orangutan, Gibbon, Monkey, Rat, Rabbit (tested or 100% immunogen sequence identity)
Predicted
Bovine, Goat, Pig (at least 90% immunogen sequence identity)
Clonality
IgG Polyclonal
Conjugations
Horseradish Peroxidase. Also available Unconjugated or conjugated with Biotin, FITC.
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin
  • Western blot
  • (applications tested for the base form of this product only)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
CHI3L1 / YKL-40 antibody was raised against synthetic peptide located between aa198-247 of human CHI3L1 (P36222, NP_001267). Percent identity by BLAST analysis: Human, Chimpanzee, Orangutan, Gibbon, Monkey, Marmoset, Elephant, Rabbit (100%); Galago, Goat, Bovine, Pig (92%); Rat (76%).
Epitope
aa198-247
Specificity
Human CHI3L1 / YKL-40
Usage
The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.
Presentation
100 mM sodium phosphate, pH 7.6, 150 mM NaCl
Storage
Short term: store at 4°C. Long term: add glycerol to 40-50%, aliquot to avoid freeze-thaw cycles, and store at -20°C. Protect from light.
Restrictions
For research use only.
About CHI3L1 / YKL-40
Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. P36222 NM_001276 NP_001267.2


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Images

Immunohistochemistry

Anti-YKL-40 / CHI3L1 antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 2.5-5 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-YKL-40 / CHI3L1 antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 2.5-5 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Western blot

HEPG2 cell lysate. Antibody concentration: 0.5 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
HEPG2 cell lysate. Antibody concentration: 0.5 ug/ml. Gel concentration: 12%. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Immunohistochemistry

Anti-YKL-40 / CHI3L1 antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 2.5-5 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-YKL-40 / CHI3L1 antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 2.5-5 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Western blot

HEPG2 cell lysate. Antibody concentration: 0.5 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
HEPG2 cell lysate. Antibody concentration: 0.5 ug/ml. Gel concentration: 12%. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Immunohistochemistry

Anti-YKL-40 / CHI3L1 antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 2.5-5 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-YKL-40 / CHI3L1 antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 2.5-5 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Western blot

HEPG2 cell lysate. Antibody concentration: 0.5 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
HEPG2 cell lysate. Antibody concentration: 0.5 ug/ml. Gel concentration: 12%. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Immunohistochemistry

Anti-YKL-40 / CHI3L1 antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 2.5-5 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-YKL-40 / CHI3L1 antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 2.5-5 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Western blot

HEPG2 cell lysate. Antibody concentration: 0.5 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
HEPG2 cell lysate. Antibody concentration: 0.5 ug/ml. Gel concentration: 12%. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Requested From: United States
Date Requested: 11/12/2018

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