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CD71 / Transferrin Receptor

Transferrin Receptor

Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system By similarity. A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site.

Gene Name: Transferrin Receptor
Family/Subfamily: Protease , Metallopeptidase M28B
Synonyms: TFRC, CD71, TFR1, TRFR, TFR, TR, CD71 antigen, p90, T9, Transferrin receptor, Transferrin receptor protein 1
Target Sequences: NM_003234 NP_003225.2 P02786

Publications (2)

1
LC3-dependent EV loading and secretion (LDELS) promotes TFRC (transferrin receptor) secretion via extracellular vesicles. Jackson O Gardner, Andrew M Leidal, Tan A Nguyen, Jayanta Debnath. Autophagy. 2023 May;19:1551-1561. [Full Text Article] [PubMed:36286616] [PMC:PMC10240981] Related Antibodies: LS-C171694.
2
HIV-1 Tat interacts with and regulates the localization and processing of amyloid precursor protein. Kim J, Yoon JH, Kim YS. PloS one. 2013 8:e77972. [Full Text Article] [PubMed:24312169] [PMC:PMC3843664] Related Antibodies: LS-B6156.

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Antibodies (285)
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CD71 / Transferrin Receptor (337)
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CD71 / Transferrin Receptor Antibody - Human Thymus: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Cancer Pathology
Cancer
CD71 / Transferrin Receptor Mouse anti-Human Monoclonal (1E6) Antibody
Human
ELISA, IHC-P, WB
Unconjugated
50 µg/$485
CD71 / Transferrin Receptor Antibody - Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Cancer Pathology
Cancer
CD71 / Transferrin Receptor Mouse anti-Human Monoclonal (aa3-28) (H68.4) Antibody
Chicken, Rat, Hamster, Mouse, Human
ELISA, ICC, IF, IHC-P, IP, WB
Unconjugated
50 µg/$485
CD71 / Transferrin Receptor Antibody - Anti-Transferrin Receptor antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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CD71 / Transferrin Receptor Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
CD71 / Transferrin Receptor Antibody -  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
CD71 / Transferrin Receptor Rabbit anti-Human Polyclonal (N-Terminus) (Magnetic beads) Antibody
Human
IP
Magnetic beads Conjugated
100 µg/$399
CD71 / Transferrin Receptor Antibody - Formalin-fixed and paraffin-embedded human brain tissue reacted with CD71 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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CD71 / Transferrin Receptor Rabbit anti-Human Polyclonal (aa649-677) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
400 µl/$393
Select
CD71 / Transferrin Receptor Mouse anti-Human Monoclonal (N-Terminus) (3G291) Antibody
Chicken, Rat, Hamster, Mouse, Human
ELISA, ICC, IP, WB
Unconjugated
250 µg/$890; 500 µg/$1,453
Select
CD71 / Transferrin Receptor Mouse anti-Rat Monoclonal (Low Endotoxin) (OX-26) Antibody
Rat
Flo, IF, IHC-Fr, IHC-P, WB
Unconjugated, Low Endotoxin
0.5 mg/$712
Select
CD71 / Transferrin Receptor Rat anti-Mouse Monoclonal (Low Endotoxin) (8D3) Antibody
Mouse
Flo, IHC, IHC-Fr
Unconjugated, Low Endotoxin
0.5 mg/$671
CD71 / Transferrin Receptor Antibody - Immunochemical staining of mouse TFRC in mouse small intestine with rabbit polyclonal antibody at 1:1000 dilution, formalin-fixed paraffin embedded sections.
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CD71 / Transferrin Receptor Rabbit anti-Mouse Polyclonal (Preservative Free) Antibody
Mouse
ELISA, IHC-P
Unconjugated, Preservative Free
100 µl/$412
Select
CD71 / Transferrin Receptor Mouse anti-Rat Monoclonal (OX-26) Antibody
Rat
Flo, IHC, IHC-Fr, IP
Unconjugated
250 µg/$359
CD71 / Transferrin Receptor ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.78 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
CD71 / Transferrin Receptor ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$715
CD71 / Transferrin Receptor Protein - Recombinant Transferrin Receptor By SDS-PAGE
Select
E. coli
His, N-Terminal
21.3 kDa
10 µg/$281; 50 µg/$440; 100 µg/$702; 200 µg/$877; 1 mg/$1,983; 500 µg/$1,523; 5 mg/$3,067; 2 mg/$2,170
CD71 / Transferrin Receptor Protein - Recombinant Transferrin Receptor By SDS-PAGE
Select
E. coli
His, N-Terminal
27.4 kDa
10 µg/$267; 50 µg/$352; 100 µg/$562; 200 µg/$702; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,673; 2 mg/$1,900
Select
HEK 293 Cells
Human IgG1 Fc, N-terminus
SDS-PAGE
Less than 1.0 EU/µg protein (determined by LAL method).
The recombinant human TFRC consists of 932 amino acids and predicts a molecular mass of 103.6 kDa.
50 µg/$364; 500 µg/$1,452
CD71 / Transferrin Receptor Antibody - TFRC antibody (1 ug/ml) staining of Human Breast lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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CD71 / Transferrin Receptor Goat anti-Human Polyclonal (aa21-35) Antibody
Rabbit, Dog, Bovine, Hamster, Pig, Horse, Human
Peptide-ELISA, WB
Unconjugated
100 µg/$503
CD71 / Transferrin Receptor ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$750
Select
CD71 / Transferrin Receptor Mouse anti-Human Monoclonal (Low Endotoxin) (DF1513) Antibody
Human
Flo, IF
Unconjugated, Low Endotoxin
0.5 mg/$671
CD71 / Transferrin Receptor Antibody - Immunohistochemistry of paraffin-embedded human lung cancer tissue.
Select
CD71 / Transferrin Receptor Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
CD71 / Transferrin Receptor Antibody - IHC of CD71 on FFPE Bone Marrow tissue.
Select
CD71 / Transferrin Receptor Mouse anti-Human Monoclonal (10F11) Antibody
Human
IHC, IHC-Fr, IHC-P
Unconjugated
0.1 ml/$309
Select
CD71 / Transferrin Receptor Rabbit anti-Cynomolgus Polyclonal Antibody
Cynomolgus
ELISA
Unconjugated
100 µl/$412
CD71 / Transferrin Receptor ELISA Kit
Select
Sandwich
96-Well Microplate
Human
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
CD71 / Transferrin Receptor ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
10 - 250 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
CD71 / Transferrin Receptor Protein
Select
E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
Select
Mammalian Cells
His,N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
77 kDa
10 µg/$266; 50 µg/$335
Viewing 1-25 of 337 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).