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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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CD59 Antibody (clone MACIF/629) LS‑C391303
CD59 antibody LS-C391303 is an unconjugated mouse monoclonal antibody to human CD59. Validated for Flow, IF and IHC.
Catalog
Size
Price
LS-C391303-20
20 µg (0.2 mg/ml)
$255
LS-C391303-100
100 µg
$395

Popular CD59 Products

Anti-CD59 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B1960 concentration 10 ug/ml.
Species: Human, Baboon, Monkey
Applications: IHC, IHC - Paraffin, Flow Cytometry
Anti-CD59 antibody IHC of human skin, pilosebaceous unit. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B1853 concentration 5 ug/ml.
Species: Human, Mouse
Applications: IHC, IHC - Paraffin, Western blot, Immunoprecipitation, Flow Cytometry
Antibody
Species: Human
Applications: Flow Cytometry
Antibody
Species: Rat
Applications: IHC, IHC - Frozen, Western blot, Flow Cytometry, Functional Assay
Anti-CD59 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B1619 concentration 20 ug/ml.
Species: Human
Applications: IHC, IHC - Paraffin, Flow Cytometry

Product Description

CD59 antibody LS-C391303 is an unconjugated mouse monoclonal antibody to human CD59. Validated for Flow, IF and IHC.
About CD59
CD59 is a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. P13987 NM_000611 NP_000602.1

CD59 Antibody, 16.3A5 Antibody, 1F5 Antibody, 1F5 antigen Antibody, CD59 glycoprotein Antibody, EL32 Antibody, EJ16 Antibody, G344 Antibody, HRF-20 Antibody, MAC-IP Antibody, MACIF Antibody, Ly-6-like protein Antibody, MEM43 Antibody, MIRL Antibody, MEM43 antigen Antibody, MIN2 Antibody, MIN3 Antibody, MSK21 Antibody, p18-20 Antibody, Protectin Antibody, MAC-inhibitory protein Antibody, MIC11 Antibody, T cell-activating protein Antibody, CD59 antigen Antibody, EJ30 Antibody, HRF20 Antibody, Human leukocyte antigen MIC11 Antibody, Lymphocytic antigen CD59/MEM43 Antibody, MIN1 Antibody


Specifications

Target
Human CD59
Host
Mouse
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
IgG1,k Monoclonal [MACIF/629]
Conjugations
Unconjugated
Purification
Protein G purified
Modifications
Unmodified. Also available Azide-free, Ready-to-Use.
Applications
  • IHC
  • IHC - Paraffin (1 - 2 µg/ml)
  • Immunofluorescence (0.5 - 1 µg/ml)
  • Flow Cytometry (0.5 - 1 µg/10E6 cells)
  • (applications tested for the base form of this product only)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
CD59 antibody was raised against recombinant Full-length Human Protein.
Specificity
Human CD59
Usage
Reacts with human CD59, a 20kDa glycosyl phosphatidyl-inositol (GPI)-anchored cell surface protein. CD59 regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. It inhibits formation of MAC, thus protecting cells from complement-mediated lysis. Genetic defects in GPI-anchor attachment, that cause a reduction or loss of CD59 and CD55 on erythrocytes produce the symptoms of the disease paroxysmal hemoglobinuria (PNH). This MAb is useful for study on GPI-anchored proteins, PNH and CD59 functions. CD59 is widely distributed on cells in all tissues. The expression of CD59 on erythrocytes is important for their survival. Optimal dilution of the CD59 antibody should be determined by the researcher. Staining of formalin-fixed tissues is enhanced by boiling tissue sections in 10mM Citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 min.
Presentation
0.01% BSA, 0.05% sodium azide
Storage
Store at 2°C to 8°C.
Restrictions
For research use only.

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Images

Immunohistochemistry

Formalin-fixed, paraffin-embedded human tonsil stained with CD59 antibody (MACIF/629).  This image was taken for the unmodified form of this product. Other forms have not been tested.
Formalin-fixed, paraffin-embedded human tonsil stained with CD59 antibody (MACIF/629). This image was taken for the unmodified form of this product. Other forms have not been tested.

Immunohistochemistry

Formalin-fixed, paraffin-embedded human tongue stained with CD59 antibody (MACIF/629).  This image was taken for the unmodified form of this product. Other forms have not been tested.
Formalin-fixed, paraffin-embedded human tongue stained with CD59 antibody (MACIF/629). This image was taken for the unmodified form of this product. Other forms have not been tested.

Immunohistochemistry

Formalin-fixed, paraffin-embedded human tonsil stained with CD59 antibody (MACIF/629).  This image was taken for the unmodified form of this product. Other forms have not been tested.
Formalin-fixed, paraffin-embedded human tonsil stained with CD59 antibody (MACIF/629). This image was taken for the unmodified form of this product. Other forms have not been tested.

Immunohistochemistry

Formalin-fixed, paraffin-embedded human tongue stained with CD59 antibody (MACIF/629).  This image was taken for the unmodified form of this product. Other forms have not been tested.
Formalin-fixed, paraffin-embedded human tongue stained with CD59 antibody (MACIF/629). This image was taken for the unmodified form of this product. Other forms have not been tested.

Immunohistochemistry

Formalin-fixed, paraffin-embedded human tonsil stained with CD59 antibody (MACIF/629).  This image was taken for the unmodified form of this product. Other forms have not been tested.
Formalin-fixed, paraffin-embedded human tonsil stained with CD59 antibody (MACIF/629). This image was taken for the unmodified form of this product. Other forms have not been tested.

Immunohistochemistry

Formalin-fixed, paraffin-embedded human tongue stained with CD59 antibody (MACIF/629).  This image was taken for the unmodified form of this product. Other forms have not been tested.
Formalin-fixed, paraffin-embedded human tongue stained with CD59 antibody (MACIF/629). This image was taken for the unmodified form of this product. Other forms have not been tested.

Immunohistochemistry

Formalin-fixed, paraffin-embedded human tonsil stained with CD59 antibody (MACIF/629).  This image was taken for the unmodified form of this product. Other forms have not been tested.
Formalin-fixed, paraffin-embedded human tonsil stained with CD59 antibody (MACIF/629). This image was taken for the unmodified form of this product. Other forms have not been tested.

Immunohistochemistry

Formalin-fixed, paraffin-embedded human tongue stained with CD59 antibody (MACIF/629).  This image was taken for the unmodified form of this product. Other forms have not been tested.
Formalin-fixed, paraffin-embedded human tongue stained with CD59 antibody (MACIF/629). This image was taken for the unmodified form of this product. Other forms have not been tested.

Requested From: United States
Date Requested: 9/20/2018

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