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CD34

CD34 molecule

CD34 is a monomeric cell surface antigen with a molecular mass of approximately 110 kD that is selectively expressed on human hematopoietic progenitor cells. CD34 is a member of a family of single-pass transmembrane sialomucin proteins that show expression on early hematopoietic and vascular-associated tissue. CD34 is also an important adhesion molecule and is required for T cells to enter lymph nodes. It is expressed on lymph node endothelia whereas the L-selectin to which it binds is on the T cell.

Gene Name:	CD34 molecule
Synonyms:	CD34, CD34 molecule, CD34 antigen, HPCA1
Target Sequences:	NM_001773 NP_001764.1 P28906

Publications (13)

Characterization of MEC 14.7, a new monoclonal antibody recognizing mouse CD34: a useful reage for identifying and characterizing blood vessels and hematopoietic precursors. Garlanda C, Berthier R, Garin J, Stoppacciaro A, Ruco L, Vittet D, Gulino D, Matteucci C, Mantovani A, Vecchi A, Dejana E. European journal of cell biology. 1997 73:368-77. [PubMed:9270880]

A general strategy for isolation of endothelial cells from murine tissues. Characterization of two endothelial cell lines from the murine lung and subcutaneous sponge implants. Dong QG, Bernasconi S, Lostaglio S, De Calmanovici RW, Martin-Padura I, Breviario F, Garlanda C, Ramponi S, Mantovani A, Vecchi A. Arteriosclerosis, thrombosis, and vascular biology. 1997 17:1599-604. [PubMed:9301641]

Differential responsiveness to constitutive vs. inducible chemokines of immature and mature mouse dendritic cells. Vecchi A, Massimiliano L, Ramponi S, Luini W, Bernasconi S, Bonecchi R, Allavena P, Parmentier M, Mantovani A, Sozzani S. Journal of leukocyte biology. 1999 66:489-94. [PubMed:10496320]

Enrichment for living murine keratinocytes from the hair follicle bulge with the cell surface marker CD34. Trempus CS, Morris RJ, Bortner CD, Cotsarelis G, Faircloth RS, Reece JM, Tennant RW. The Journal of investigative dermatology. 2003 120:501-11. (ICC, IHC, Flo) [PubMed:12648211]

Organogenesis from dissociated cells: generation of mature cycling hair follicles from skin-derived cells. Zheng Y, Du X, Wang W, Boucher M, Parimoo S, Stenn K. The Journal of investigative dermatology. 2005 124:867-76. (IHC-P) [PubMed:15854024]

Generation and characterization of a mouse lymphatic endothelial cell line. Sironi M, Conti A, Bernasconi S, Fra AM, Pasqualini F, Nebuloni M, Lauri E, De Bortoli M, Mantovani A, Dejana E, Vecchi A. Cell and tissue research. 2006 325:91-100. [PubMed:16534603]

A subpopulation of mouse esophageal basal cells has properties of stem cells with the capacity for self-renewal and lineage specification. Kalabis J, Oyama K, Okawa T, Nakagawa H, Michaylira CZ, Stairs DB, Figueiredo JL, Mahmood U, Diehl JA, Herlyn M, Rustgi AK. The Journal of clinical investigation. 2008 118:3860-9. [PubMed:19033657] [PMC:PMC2579884]

The mobilization and effect of endogenous bone marrow progenitor cells in diabetic wound healing. Fiorina P, Pietramaggiori G, Scherer SS, Jurewicz M, Mathews JC, Vergani A, Thomas G, Orsenigo E, Staudacher C, La Rosa S, Capella C, Carothers A, Zerwes HG, Luzi L, Abdi R, Orgill DP. Cell transplantation. 2010 19:1369-81. [PubMed:20977829]

Endothelial cell HIF-1 and HIF-2 differentially regulate metastatic success. Branco-Price C, Zhang N, Schnelle M, Evans C, Katschinski DM, Liao D, Ellies L, Johnson RS. Cancer cell. 2012 21:52-65. [PubMed:22264788] [PMC:PMC3334270]

Effects of Sorafenib Dose on Acquired Reversible Resistance and Toxicity in Hepatocellular Carcinoma. Kuczynski EA, Lee CR, Man S, Chen E, Kerbel RS. Cancer research. 2015 June;75:2510-9. (Mouse) [Full Text Article] [PubMed:25908587]

Macrophages form functional vascular mimicry channels in vivo. Barnett FH, Rosenfeld M, Wood M, Kiosses WB, Usui Y, Marchetti V, Aguilar E, Friedlander M. Scientific reports. 2016 November;6:36659. (Mouse) [Full Text Article] [PubMed:27834402] [PMC:PMC5105153] Related Antibodies: LS-C62600.

Low-Level Laser Irradiation Promotes Proliferation and Differentiation on Apical Papilla Stem Cells. David Gutiérrez, Mahmoud Rouabhia, Javiera Ortiz, Diego Gaviria, Camilo Alfonso, Ana Muñoz, Carolina Inostroza. Journal of lasers in medical sciences. 2022 February;12:e75. [Full Text Article] [PubMed:35155160] [PMC:PMC8837851] Related Antibodies: LS-C204500.

Vascular endothelial growth inhibitor 174 is a negative regulator of aggressiveness and microvascular density in human clear cell renal cell carcinoma. Wu L, Li X, Ye L, Shayiremu D, Deng X, Zhang X, Jiang W, Yang Y, Gong K, Zhang N. Anticancer research. 2014 Feb;34:715-22. [Full Text Article] [PubMed:24511004] Related Antibodies: LS-B5262.

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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