(tested or 100% immunogen sequence identity)
Ion exchange chromatography
Normal human peripheral blood granulocytes.
Recognizes CD16, a 50-65 kD cell surface molecule which exists in two forms - a transmembranous form expressed by NK cells and some T cells, and a phosphatidylinositol linked form expressed by granulocytes. CD16 is a low affinity receptor for IgG (FcR III), and is an important receptor mediating ADCC by NK cells. Has been reported to block the binding of IgG to the CD16 molecule.