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The chaperonin containing TCP1 (MIM 186980) complex (CCT), also called the TCP1 ring complex, consists of 2 back-to-back rings, each containing 8 unique but homologous subunits, such as CCT4. CCT assists the folding of newly translated polypeptide substrates through multiple rounds of ATP-driven release and rebinding of partially folded intermediate forms. Substrates of CCT include the cytoskeletal proteins actin (see MIM 102560) and tubulin (see MIM 191130), as well as alpha-transducin (MIM 139330) (Won et al., 1998 [PubMed 9819444]).
Gene Name: | chaperonin containing TCP1, subunit 4 (delta) |
Synonyms: | CCT4, CCT-DELTA, Cctd, SRB, Stimulator of TAR RNA-binding, TCP-1-delta |
Target Sequences: | NM_006430 NP_006421.2 P50991 |
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