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Catalog Number Size Price
LS-C743983-50 50 µg $1,335 
Antibody

Carboxyethyl Lysine Antibody LS‑C743983

Carboxyethyl Lysine Antibody LS‑C743983

Antibody:
Mouse Monoclonal to Carboxyethyl Lysine
Application:
IHC, ELISA
Format:
Unconjugated, Unmodified
Price
Catalog Number
$1,335 
LS-C743983-50
50 µg
Toll Free North America
866-819-4732

Overview

Antibody:
Mouse Monoclonal to Carboxyethyl Lysine
Application:
IHC, ELISA
Format:
Unconjugated, Unmodified

Specifications

Description
Carboxyethyl Lysine antibody LS-C743983 is an unconjugated mouse monoclonal antibody to Carboxyethyl Lysine. Validated for ELISA and IHC.
Target
Carboxyethyl Lysine
Host
Mouse
Clonality
IgG1 Monoclonal
Conjugations
Unconjugated
Modifications
Unmodified
Applications
  • IHC (2 µg/ml)
  • ELISA (0.1 - 0.5 µg/ml)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
N-epsilon-(Carboxyethyl)-Lysine-BSA
Usage
This antibody is suitable for the detection of CEL in tissues and tissue extracts. Long-term incubation of proteins with glucose leads, through Schiff's base and Amadori rearrangement products, to the formation of advanced glycation end products (AGE) which are characterized by fluorescence, brown color and inter- and intra-molecular cross-linking. Recent immunological studies using anti-AGE antibodies demonstrated the presence of AGE in (i) human lens, (ii) renal proximal tubules in patients with diabetic nephropathy and chronic renal failure, (iii) atherosclerotic lesions of arterial walls, (iv) ß2-microglobulin of carpal tunnel amyloid fibril deposits in patients with hemodialysis-related amyloidosis and (v) brain tissues of patients with Alzheimer's disease. According to McLellan et al. (1994) CEL is formed as a reaction product of methylglyoxal (MG) with proteins in diabetes patients. In these patiens up to 7 times higher MG-values were measured in comparison to healthy subjects. In lenses of diabetic patients CEL concentration was found to be as high as that of CML [N-epsilon-(carboxymethyl)lysine].
Presentation
Stabilized buffer, 50% block ace, 0.1% proclin
Storage
Store at -20°C.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee

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Requested From: United States
Date Requested: 10/15/2019