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GM2 and GD2 gangliosides are sialic acid-containing glycosphingolipids. GalNAc-T is the enzyme involved in the biosynthesis of G(M2) and G(D2) glycosphingolipids. GalNAc-T catalyzes the transfer of GalNAc into G(M3) and G(D3) by a beta-1,4 linkage, resulting in the synthesis of G(M2) and G(D2), respectively. Three transcript variants encoding different isoforms have been found for this gene.
Gene Name: | beta-1,4-N-acetyl-galactosaminyl transferase 1 |
Synonyms: | B4GALNT1, Beta1-4GalNAc-T, Beta1,4GalNAc-T, GM2/GD2 synthase, GALNACT, GD2 synthase, GM2 synthase, SIAT2, GALGT, GalNAc-T |
Target Sequences: | NM_001478 NP_001469.1 Q00973 |
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