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Catalog Number Size Price
LS-C42572-50 50 µg (0.2 mg/ml) $410 
Antibody

Polyclonal Rabbit anti‑Human AURKB / Aurora‑B Antibody (aa227‑238, WB) LS‑C42572

Polyclonal Rabbit anti‑Human AURKB / Aurora‑B Antibody (aa227‑238, WB) LS‑C42572

Antibody:
AURKB / Aurora-B Rabbit anti-Human Polyclonal (aa227-238) Antibody
Application:
WB, ELISA
Reactivity:
Human
Format:
Unconjugated, Unmodified
Price
Catalog Number
$410
LS-C42572-50
Toll Free North America
866-819-4732
For Research Use Only

Overview

Antibody:
AURKB / Aurora-B Rabbit anti-Human Polyclonal (aa227-238) Antibody
Application:
WB, ELISA
Reactivity:
Human
Format:
Unconjugated, Unmodified

Specifications

Description
Aurora-B antibody LS-C42572 is an unconjugated rabbit polyclonal antibody to human Aurora-B (AURKB) (aa227-238). Validated for ELISA and WB.
Target
Human AURKB / Aurora-B
Synonyms
AURKB | AIRK2 | AIK2 | Aurora kinase B | Aurora kinase B-Sv1 | Aurora-related kinase 2 | Aurora/IPL1-related kinase 2 | ARK-2 | ARK2 | Aurkb-sv1 | Aurkb-sv2 | Aurora 1 | Aurora-B | AIM-1 | IPL1 | STK-1 | STK5 | PPP1R48 | AurB | Aurora B | Aurora kinase B-Sv2 | Aurora-1 | Aurora1 | Serine/threonine kinase 12 | STK1 | STK12
Host
Rabbit
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
IgG Polyclonal
Conjugations
Unconjugated
Purification
Purified
Modifications
Unmodified
Immunogen
Synthetic peptide corresponding to aa227-238 of human Aurora-B kinase.
Epitope
aa227-238
Specificity
Detects Aurora-B kinase (AurB), a serine/threonine kinase which is the enzymatic core of the Chromosomal Passenger Complex (CPC). This complex functions in chromosome alignment and separation, histone modification, and cytokinesis. CPC also includes three non-enzymatic subunits known as the inner centromere protein (INCENP), survivin, and borealin, which determine the activity, localization, stability, and possibly even the substrate specificity of AurB. Two CPCs exist during mitosis- one containing all four members, and another consisting of INCENP and AurB. Quaternary CPC functions during chromosome alignment and cytokinesis, whereas the INCENP-AurB complex may be responsible for modifying histone H3. AurB is overexpressed in a number of tumors, including primary breast and colon tumor samples. Its expression in tumors seems to be linked with Aurora-A kinase, suggesting a feedback mechanism between the two proteins.
Applications
  • Western blot (1:250 - 1:1000)
  • ELISA (1:2000 - 1:10000)
Usage
Western Blot: LS-C42572 detects a band of approximately 39kD in HeLa cell lysates.
Presentation
PBS, 0.09% Sodium Azide
Storage
Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About AURKB / Aurora-B
Q96GD4 NM_004217 NP_004208.2

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Request SDS/MSDS

To request an SDS/MSDS form for this product, please contact our Technical Support department at:

Technical.Support@LSBio.com

Requested From: United States
Date Requested: 9/27/2021