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Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 2, like arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for arrestin beta 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Gene Name: | arrestin, beta 2 |
Synonyms: | ARRB2, Arrestin 3, Arrestin beta-2, ARB2, ARR2, BARR2, Arrestin, beta 2, Beta-arrestin-2 |
Target Sequences: | NM_004313 NP_004304.1 P32121 |
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