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ZNF197 belongs to the zinc finger protein superfamily, members of which are regulatory proteins characterized by nucleic acid-binding zinc finger domains. The encoded protein contains 20 tandemly arrayed C2H2-type zinc fingers, a Kruppel-associated box (KRAB) domain, and a SCAN box. This transcript turns over rapidly and contains 3' UTR AUUUA motifs, which are often a hallmark of rapid turnover. It is overexpressed in some thyroid papillary carcinomas. This gene is located in a cluster of zinc finger genes at 3p21. Two alternatively spliced transcripts encoding different isoforms have been described.
Gene Name: | zinc finger protein 197 |
Family/Subfamily: | Zinc Finger |
Synonyms: | ZNF197, Zinc finger protein 166, VHLaK, Zinc finger protein 20, ZSCAN41, Zinc finger protein 197, ZKSCAN9, D3S1363E, p18, ZNF166 |
Target Sequences: | NM_006991 NP_008922.1 O14709 |
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