Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Human (tested or 100% immunogen sequence identity)
Monkey (at least 90% immunogen sequence identity)
Western blot (1:128000) & (0.5 - 1.5 µg/ml)
Specificity and Use
ZMPSTE24 antibody was raised against synthetic peptide C-ERLQALKTMKQH from the C-terminus of human ZMPSTE24 (NP_005848.2). Percent identity by BLAST analysis: Human, Gorilla, Orangutan, Gibbon (100%); Monkey (92%); Marmoset, Rabbit (83%).
LS-E26172 - Lyophilized - 100 µg - $145.00
Immunizing peptide used to generate LS-C54807. Useful for pre-absorption and neutralization of the antibody's antigen binding site.
ZMPSTE24 is a member of the peptidase M48A family. The encoded protein is a zinc metalloproteinase involved in the two step post-translational proteolytic cleavage of carboxy terminal residues of farnesylated prelamin A to form mature lamin A. Mutations in this gene have been associated with mandibuloacral dysplasia and restrictive dermopathy.