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Anti-YWHAQ / 14-3-3 Theta Antibody (N-Terminus) LS-C42376

Ordering

Wt. Vol. Conc. Price
- 100 µl - $395
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
Orders@LSBio.com
 

Most Popular YWHAQ / 14-3-3 Theta Antibodies

Anti-YWHAQ / 14-3-3 Theta Antibody (aa1-245, clone AT1A1) IHC-plus™ LS-B2967
Mouse Monoclonal [clone AT1A1] (IgG1) to Human YWHAQ / 14-3-3 Theta
Human
IHC - Paraffin, Western blot, ELISA
Unconjugated
Immunohistochemistry Image
Anti-YWHAQ / 14-3-3 Theta Antibody (clone 33A) LS-C193556
Mouse Monoclonal [clone 33A] (IgG2a) to Human YWHAQ / 14-3-3 Theta
Human
IHC, Western blot
Unconjugated
Anti-YWHAQ / 14-3-3 Theta Antibody (aa45-94) IHC-plus™ LS-B11976
Rabbit Polyclonal (IgG) to Human YWHAQ / 14-3-3 Theta
Human, Monkey, Mouse, Rat, Bat, Bovine, Dog, Guinea pig, Hamster, Horse, Pig, Rabbit, Xenopus, Zebrafish
IHC - Paraffin, Western blot
Unconjugated
Immunohistochemistry Image

100% Guaranteed 100% Guaranteed
Rabbit Polyclonal (IgG) to Sheep YWHAQ / 14-3-3 Theta
Sheep, Human, Mouse, Rat, Bovine, Rabbit, Chicken
IHC - Paraffin, Western blot, ELISA
Unconjugated

Details

Sheep YWHAQ / 14-3-3 Theta
Rabbit
Sheep, Human, Mouse, Rat, Bovine, Rabbit, Chicken (tested or 100% immunogen sequence identity)
Mammal (at least 90% immunogen sequence identity)
IgG Polyclonal
Unconjugated
Unmodified

Applications

  • IHC - Paraffin (1:60)
  • Western blot (1:3000)
  • ELISA

Specificity and Use

YWHAQ / 14-3-3 Theta antibody was raised against synthetic peptide corresponding to acetylated N-terminal sequence of sheep 14-3-3 tau/theta.
N-Terminus
Recognizes 14-3-3 tau/theta in all mammals. It is a member of the 14-3-3 family which consists of 30 kD proteins involved in multiple cell signalling pathways, regulation of cell cycle progression, cytoskeletal structure, transcription, intracellular trafficking and targeting. Protein interactions with 14-3-3 show distinct preferences for it's different isoforms and are regulated by phosphorylation of both 14-3-3 and the bound protein. 14-3-3 tau/theta is primarily expressed in T-cells although it occurs at lower levels in the brain, heart, pancreas placenta and kidneys. It plays a role in cell cycle progression via interaction with p27(Kip1). Along with COPI, the theta isoform binds the GB1 RSR sequence involved in protein trafficking. The isoform forms a complex with Hsp60 and cellular prion protein which may be involved in prion diseases. Elevated levels of 14-3-3 tau/theta are observed in amyotrophic lateral sclerosis. 14-3-3 tau/theta also binds BCR/Abl, bacterial effector protein Tir, yes-associated protein and the FSH receptor. May not react with recombinant proteins that are not N-acetylated.
Western Blot: LS-C42376 detects a band of approximately 30kD in HEK293 cell lysates. Immunohistology: This product requires antigen retrieval using heat treatment prior to staining of paraffin sections.

Packaging

Serum, 0.09% sodium azide.
Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
For research use only.

About YWHAQ / 14-3-3 Theta

P27348 NM_006826 NP_006817.1

YWHAQ Antibody, 14-3-3 protein T-cell Antibody, 14-3-3 protein theta Antibody, 14-3-3 protein tau Antibody, 14-3-3 Antibody, 14-3-3 Tau Antibody, 1C5 Antibody, Protein HS1 Antibody, HS1 Antibody, Protein tau Antibody

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.

Requested From: United States
Date Requested: 12/8/2016

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