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The protein encoded by this gene functions together with DNA ligase IV and the DNA-dependent protein kinase in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. The non-homologous end-joining pathway is required both for normal development and for suppression of tumors. This gene functionally complements XR-1 Chinese hamster ovary cell mutant, which is impaired in DNA double-strand breaks produced by ionizing radiation and restriction enzymes. This gene contains 8 exons, and alternative transcription initiation and alternative splicing generates several transcript variants.
Gene Name: | X-ray repair complementing defective repair in Chinese hamster cells 4 |
Family/Subfamily: | DNA repair |
Synonyms: | XRCC4, DNA repair protein XRCC4 |
Target Sequences: | NM_022550 NP_072044.1 Q13426 |
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