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Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHEK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation.
Gene Name: | xeroderma pigmentosum, complementation group A |
Synonyms: | XPA, XP1, XPAC, Excision repair-controlling |
Target Sequences: | NM_000380 NP_000371.1 P23025 |
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