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Anti-WNK4 Antibody (Internal) LS-C11071

Ordering

Wt. Vol. Conc. Price
50 µg - - Unavailable
100 µg - - Unavailable

Related Products

Most Popular WNK4 Antibodies

Anti-WNK4 Antibody (aa200-300, Biotin) LS-C142341
Rabbit Polyclonal to Human WNK4
Human, Mouse, Rat
IHC, IHC - Paraffin, Western blot
Biotin Conjugated
Immunohistochemistry Image
Anti-WNK4 Antibody (aa200-300, DY650) LS-C142342
Rabbit Polyclonal to Human WNK4
Human, Rat
IHC, IHC - Paraffin, Western blot
DY650 Conjugated
Immunohistochemistry Image
Anti-WNK4 Antibody (aa200-300, DY488) LS-C142343
Rabbit Polyclonal to Human WNK4
Human, Rat
IHC, IHC - Paraffin, Western blot
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100% Guaranteed 100% Guaranteed
Rabbit Polyclonal (IgG) to Human WNK4
Human
Western blot, ELISA
Unconjugated

Details

Human WNK4
Rabbit
Human (tested or 100% immunogen sequence identity)
IgG Polyclonal
Unconjugated
Immunoaffinity purified
Unmodified

Applications

  • Western blot (1:1000 - 1:5000)
  • ELISA (1:10000 - 1:100000)

Specificity and Use

WNK4 antibody was raised against a 13-aa peptide sequence, mapping at the middle (around ~650-aa) region of human WNK-4 (1) synthesized, coupled to KLH.
Internal
Peptide sequences from other species are not yet available. No significant sequence homology of is seen with other WNKs or proteins. Antibody reactivity in various species is not established. The control peptide, because of its low MW (<3kD), is not suitable for Western. It should be used for ELISA or antibody blocking experiments (use 5-10 ug control peptide per 1 ug of aff pure IgG or 1 ul antiserum) to confirm antibody specificity.
Suitable for use in ELISA, Western Blot. Western Blot: 1:1000-1:5000 for neat serum and 1-10 ug/ml for affinity pure using ECL. WNK4 is ~135/155kD in kidney. ELISA: 1:10000-1:100000 using 50-100 ng of control peptide/well.

Packaging

PBS, pH 7.4, 0.1% BSA
Long term: Add glycerol (40-50%) -20°C; Short term: +4°C
For research use only.

About WNK4

Q96J92 NM_032387 NP_115763.2

WNK4 Antibody, PHA2B Antibody, PRKWNK4 Antibody

Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D, SGK1, TRPV5 and TRPV6. Regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation which appears to prevent membrane trafficking of SLC12A3.

Requested From: 
Date Requested: 3/26/2017

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