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WD40 repeat proteins are key components of many essential biologic functions. They regulate the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein-protein interactions. Members of the WIPI subfamily of WD40 repeat proteins, such as WIPI2, have a 7-bladed propeller structure and contain a conserved motif for interaction with phospholipids (Proikas-Cezanne et al., 2004 [PubMed 15602573]).
Gene Name: | WD Repeat Domain, Phosphoinositide Interacting 2 |
Synonyms: | WIPI2, ATG18B, Atg21, DKFZP434J154, WIPI-2, WIPI49-like protein 2, CGI-50 |
Target Sequences: | NM_016003 NP_057087.2 |
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