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SCAR2 / WAVE2 is a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function. The published map location (PMID:10381382) has been changed based on recent genomic sequence comparisons, which indicate that the expressed gene is located on chromosome 1, and a pseudogene may be located on chromosome X. Two transcript variants encoding different isoforms have been found for this gene.
Gene Name: | WAS protein family, member 2 |
Synonyms: | WASF2, DJ393P12.2, IMD2, Protein WAVE-2, WASF4, WAVE2, SCAR2, WASP family protein member 2, WASP family protein member 4, WAS protein family, member 2 |
Target Sequences: | NM_006990 NP_008921.1 Q9Y6W5 |
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