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Specifically deubiquitinates histone H2B at 'Lys-120' (H2BK120Ub). H2BK120Ub is a specific tag for epigenetic transcriptional activation and acts as a regulator of mRNA splicing. Deubiquitination is required for efficient cotranscriptional splicing of a large set of exons.
Gene Name: | ubiquitin specific peptidase 49 |
Synonyms: | USP49, Deubiquitinating enzyme 49, Ubiquitin specific protease 49, Ubiquitin thiolesterase 49, Ubiquitin thioesterase 49 |
Target Sequences: | NM_018561 NP_061031.2 Q70CQ1 |
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