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Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta (POLB), stabilizing POLB thereby playing a role in base-excision repair (BER). Acts as a regulator of cell growth and genome integrity. May also indirectly regulates CDC25A expression at a transcriptional level.
Gene Name: | ubiquitin specific peptidase 47 |
Synonyms: | USP47, Deubiquitinating enzyme 47, Ubiquitin thiolesterase 47, Ubiquitin specific protease 47, Ubiquitin thioesterase 47, TRFP |
Target Sequences: | NM_017944 NP_060414.3 Q96K76 |
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