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Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation and cell cycle progression.
Gene Name: | ubiquitin specific peptidase 22 |
Family/Subfamily: | Protease , Cysteine C19 |
Synonyms: | USP22, KIAA1064, Ubiquitin thiolesterase 22, USP3L, Ubiquitin specific protease 22, Ubiquitin thioesterase 22, Deubiquitinating enzyme 22, KIAA1063 |
Target Sequences: | AB028986 BAA83015.1 Q9UPT9 |
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