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UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme is active on polyhydroxylated estrogens (such as estriol, 4-hydroxyestrone and 2-hydroxyestriol) and xenobiotics (such as 4-methylumbelliferone, 1-naphthol, 4-nitrophenol, 2-aminophenol, 4-hydroxybiphenyl and menthol). It is capable of 6 alpha-hydroxyglucuronidation of hyodeoxycholic acid.
Gene Name: | UDP glucuronosyltransferase 2 family, polypeptide B4 |
Synonyms: | UGT2B4, UDPGTh-1, UDPGT 2B4, UDPGT2B4, UDPGTH1, HLUG25, Hyodeoxycholic acid |
Target Sequences: | NM_021139 NP_066962.2 P06133 |
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