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E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. May be involved in pancreatic homeostasis. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth.
Gene Name: | ubiquitin protein ligase E3 component n-recognin 1 |
Synonyms: | UBR1, E3a ligase, JBS, N-recognin-1, Ubiquitin ligase E3 alpha-I |
Target Sequences: | AI192195 NP_777576.1 Q8IWV7 |
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