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Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in mitomycin-C (MMC)-induced DNA repair: acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCL and FANCI. May contribute to ubiquitination and degradation of BRCA1. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer 'Lys-11'-, 'Lys-27'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination.
Gene Name: | ubiquitin-conjugating enzyme E2T (putative) |
Synonyms: | UBE2T, PIG50, Ubiquitin carrier protein T, Ubiquitin conjugating enzyme, Ubiquitin-protein ligase T, HSPC150 |
Target Sequences: | NM_014176 NP_054895.1 Q9NPD8 |
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