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TXNRD2 is a member of the class I pyridine nucleotide-disulfide oxidoreductase family. The encoded protein is a selenocysteine-containing flavoenzyme that maintains thioredoxins in a reduced state, thereby playing a key role in regulating the cellular redox environment. Mammals have three related thioredoxin reductases. This gene encodes a mitochondrial form important for scavenging of reactive oxygen species in mitochondria. Alternatively spliced transcript variants encoding different isoforms have been described.
Gene Name: | thioredoxin reductase 2 |
Synonyms: | TXNRD2, KIAA1652, Selenoprotein Z, Thioredoxin reductase 3, TR-BETA, Thioredoxin reductase TR3, TR3, SELZ, Thioredoxin reductase beta, TR, Thioredoxin reductase 2, TRXR2 |
Target Sequences: | NM_006440 NP_006431.2 Q9NNW7 |
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