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Form a receptor-activated non-selective calcium permeant cation channel. Acts as a cell-cell contact-dependent endothelial calcium entry channel. Probably operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Mediates cation entry, with an enhanced permeability to barium over calcium. May also be activated by intracellular calcium store depletion.
Gene Name: | transient receptor potential cation channel, subfamily C, member 4 |
Family/Subfamily: | Ion Channel , Calcium channel - TRP |
Synonyms: | TRPC4, CCE1, HTRP-4, HTRP4, TRP4, STRPC4, Trrp4, Trp-related protein 4 |
Target Sequences: | NM_016179 NP_057263.1 Q9UBN4 |
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