Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
IHC, IHC - Paraffin, Western blot, Immunoprecipitation
Mouse Monoclonal [clone 4H9] (IgG1) to Human TRIP230 / TRIP11
Western blot, Immunoprecipitation
Human TRIP230 / TRIP11
Human (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [4H9]
Protein G purified
Specificity and Use
GST fusion protein corresponding to aa 1099-1372 of Trip230 expressed in E. coli.
human Trip230, a 230 kD protein. The gene for Trip230 is located on chromosome 14q31 in a region associated with genetic alterations and thyroid hormone response abnormalities. Trip230 interacts with Retinoblastoma Protein (Rb) and thyroid hormone receptor using two distinct domains
TRIP230 / TRIP11 was identified based on the interaction of its protein product with thyroid hormone receptor beta. This protein is associated with the Golgi apparatus. The N-terminal region of the protein binds Golgi membranes and the C-terminal region binds the minus ends of microtubules; thus, the protein is thought to play a role in assembly and maintenance of the Golgi ribbon structure around the centrosome. Mutations in this gene cause achondrogenesis type IA.