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TRIP230 / TRIP11 was identified based on the interaction of its protein product with thyroid hormone receptor beta. This protein is associated with the Golgi apparatus. The N-terminal region of the protein binds Golgi membranes and the C-terminal region binds the minus ends of microtubules; thus, the protein is thought to play a role in assembly and maintenance of the Golgi ribbon structure around the centrosome. Mutations in this gene cause achondrogenesis type IA.
Gene Name: | thyroid hormone receptor interactor 11 |
Synonyms: | TRIP11, ACG1A, GMAP-210, TR-interacting protein 11, TRIP230, TRIP-11, CEV14 |
Target Sequences: | NM_004239 NP_004230.2 Q15643 |
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