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Adapter protein and signal transducer that links members of the tumor necrosis factor receptor (TNFR) family to different signaling pathways. Plays a role in the activation of NF-kappa-B and JNK, and in the regulation of cell survival and apoptosis. Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. Required for normal skeleton development, and for normal development of the respiratory tract (By similarity). Required for activation of RPS6KB1 in response to TNF signaling. Modulates TRAF6 functions.
Gene Name: | TNF receptor-associated factor 4 |
Synonyms: | TRAF4, Malignant 62, RING finger protein 83, MLN 62, MLN62, RNF83, CART1 |
Target Sequences: | NM_004295 NP_004286.2 Q9BUZ4 |
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