Target
Rat TNFSF4 / OX40L / CD252
Synonyms
TNFSF4 | CD134 ligand | CD134L | CD252 antigen | Glycoprotein Gp34 | OX-40L | OX40 ligand | TXGP1 | OX40L | OX4OL | CD252 | gp34 | OX40 antigen ligand
Reactivity
Rat
(tested or 100% immunogen sequence identity)
Immunogen
ACI-S1 rat T-cell lymphoma cell line.
Specificity
Recognizes rat CD252, otherwise known as OX40L or CD134L, a 22kD type II transmembrane glycoprotein and member of the TNF superfamily, expressed by antigen-presenting cells including activated dendritic cells and B cells, and also by vascular endothelium. The interaction of CD252 with its receptor OX40/CD134, acts as a co-stimulator of T cell activation, proliferation and both Th1 and Th2 cytokine production, and is also important in activated B cell proliferation and secretion of immunoglobulins (Igs). CD252/OX40 interaction has been implicated in HTLV-1 associated diseases including myelopathy and adult T cell leukaemia, and also with the autoimmune diseases rheumatoid arthritis and inflammatory bowel disease. Clone ATM-2 has been shown to block the co-stimulatory activity of CD252 on rat T cell proliferation.