Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Rabbit Polyclonal to Human TNFRSF9 / 4-1BB / CD137
Human, Rat, Bovine, Dog, Horse, Pig
Mouse Monoclonal [clone 4B4 (4B4-1)] (IgG1,k) to Human TNFRSF9 / 4-1BB / CD137
Human TNFRSF9 / 4-1BB / CD137
Human (tested or 100% immunogen sequence identity)
IgG1,k Monoclonal [4B4 (4B4-1)]
Specificity and Use
This 4B4 (4B4-1) antibody has been pre-titrated and tested by flow cytometric analysis on ConA-stimulated normal human peripheral blood cells. This can be used at 5 ul (0.06 ug)/per test. A test is defined as the amount (ug)/test of antibody that will stain a cell sample in a final volume of 100 ul. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.
Aqeuous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
TNFRSF9 Antibody, 4-1BB ligand receptor Antibody, 4-1BB Antibody, CD137 antigen Antibody, CD137 Antibody, Homolog of mouse 4-1BB Antibody, ILA Antibody, Receptor protein 4-1BB Antibody, T cell antigen ILA Antibody, T-cell antigen 4-1BB homolog Antibody, T-cell antigen ILA Antibody, CDw137 Antibody
TNFRSF9 / 4-1BB / CD137 is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation.
Staining of ConA-activated human peripheral blood cells with APC anti-human CD69 (FN50) (LS-C107295) and 0.25 ug of FITC Mouse IgG1, K isotype control (left) or FITC anti-human 4-1BB (4B4) (right). Total viable cells were used for analysis. This image was taken for the unconjugated form of this product. Other forms have not been tested.