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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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TNFRSF10A / DR4 Antibody (clone DR‑4‑02) LS‑C204830
Antibody
DR4 antibody LS-C204830 is an unconjugated mouse monoclonal antibody to human DR4 (TNFRSF10A). Validated for Block, Flow, Func, ICC, IP and Neut.
Catalog
Size
Price
LS-C204830-100
100 µg (1 mg/ml)
Unavailable

Popular TNFRSF10A / DR4 Products

Anti-TNFRSF10A / DR4 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B604 concentration 5 ug/ml.
Species: Human
Applications: IHC, IHC - Paraffin, Western blot
Antibody
Species: Human
Applications: Flow Cytometry
Anti-TNFRSF10A / DR4 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2073 concentration 5 ug/ml.
Species: Human
Applications: IHC, IHC - Paraffin, Western blot, Flow Cytometry, Neutralization
Anti-TNFRSF10A / DR4 antibody IHC of human small intestine042998.1. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2075 concentration 5 ug/ml.
Species: Human, Mouse, Rat
Applications: IHC, IHC - Paraffin, Western blot
Antibody
Species: Human
Applications: ICC, Immunoprecipitation, Flow Cytometry, Functional Assay

Product Description

DR4 antibody LS-C204830 is an unconjugated mouse monoclonal antibody to human DR4 (TNFRSF10A). Validated for Block, Flow, Func, ICC, IP and Neut.
About TNFRSF10A / DR4
Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors, TNFR1 and Fas. A novel death domain containing receptor was recently identified and designated DR4 (for death receptor 4)1. NM_003844

TNFRSF10A Antibody, APO2 Antibody, CD261 Antibody, DR4 Antibody, TRAIL-R1 Antibody, TRAILR-1 Antibody, TRAILR1 Antibody, TRAIL receptor 1 Antibody, CD261 antigen Antibody, Cytotoxic TRAIL receptor Antibody, Death receptor 4 Antibody


Specifications

Target
Human TNFRSF10A / DR4
Host
Mouse
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
IgG1 Monoclonal [DR-4-02]
Conjugations
Unconjugated
Purification
Protein A purified
Modifications
Unmodified
Applications
  • ICC
  • Immunoprecipitation
  • Flow Cytometry
  • Blocking
  • Functional Assay
  • Neutralization
Immunogen
TNFRSF10A / DR4 antibody was raised against fusion protein containing the extracellular part of TRAIL-R1 and the constant part of the heavy chain of the human IgG1.
Specificity
Monoclonal antibody DR-4-02 recognizes TRAIL-R1 (DR4), a human death receptor 4 (468 amino acids) expressed in most human tissues (spleen, peripheral blood leucocytes, thymus) and in a variety of tumor-derived cell lines.
Usage
Flow Cytometry: Recommended dilution - 3-5 ug/ml. Functional Application: Soluble antibody DR-4-02 blocks apoptosis triggered by a ligand (TRAIL). Plastic-immobilized (cross-linked) DR-4-02 antibody induces apoptosis in sensitive cells. Recommended diluti
Presentation
PBS, pH 7.4, 15 mM sodium azide.
Storage
Store at 2-8°C. Do not freeze.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Requested From: 
Date Requested: 6/25/2018

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