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Anti-TNF Alpha Antibody (clone MP6-XT3, Low Endotoxin) LS-C187470

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Rat Monoclonal [clone MP6-XT3] (IgG1) to Mouse TNF Alpha
Mouse
Western blot, Flow Cytometry, ELISA, Functional Assay
Unconjugated, Low Endotoxin

Details

Mouse TNF Alpha
Rat
Mouse (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [MP6-XT3]
Protein G purified
Low Endotoxin

Applications

Western blot, Flow Cytometry, ELISA (1 - 5 µg/ml), Functional Assay

Specificity and Use

TNF Alpha antibody was raised against recombinant murine TNF-alpha expressed in E. coli.
Specific for mouse tumor necrosis factor alpha (TNF alpha), also known as TNFSF2. This 17kD cytokine is produced by monocytes, macrophages, neutrophils, NK cells and CD4+ T cells. TNF alpha forms dimers and trimers, and is also found as a 26kD integral membrane protein. Mouse TNF alpha has cytolytic activity against many tumor cell lines, and has an important immunoregulatory role. Clone MP6-XT3 is reported to neutralize the effects of mouse TNF alpha, see for details.

Packaging

PBS
Store at -20°C. Minimize freezing and thawing.
For research use only.

About TNF Alpha

P01375 NM_000594 NP_000585.2

TNF Antibody, APC1 protein Antibody, Cachectin Antibody, DIF Antibody, TNF Alpha Antibody, Tumor necrosis factor-alpha Antibody, TNF-alpha Antibody, TNF-a Antibody, TNFA Antibody, Tumor necrosis factor Antibody, TNF, macrophage-derived Antibody, TNF, monocyte-derived Antibody, TNFSF2 Antibody

Tumor Necrosis Factor (TNF) is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. TNF is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. TNF is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation.

Requested From: United States
Date Requested: 4/21/2015

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