Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone J1D9] (IgG1) to Human TNF Alpha
IHC, Western blot, Flow Cytometry, Functional Assay
Human TNF Alpha
Human (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [J1D9]
Protein A purified
Specificity and Use
TNF Alpha antibody was raised against recombinant human TNF alpha.
Human TNF alpha.
Function: Neutralizes TNF alpha biological activities. It prevents TNF alpha induced apoptosis in Jurkat cells. The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.
50 mM sodium phosphate, pH 7.5, 100 mM potassium chloride, 150 mM sodium chloride, 5% Glycerol, 0.2% BSA, 0.04% sodium azide
TNF Alpha is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation.