Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone T2H5] (IgG1) to Human TNC / Tenascin C
Western blot, Immunoprecipitation
Human TNC / Tenascin C
Human (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [T2H5]
Protein A purified
IHC - Paraffin
Specificity and Use
TNC / Tenascin C antibody was raised against protein preparation from a homogenate of a human mammary tumor specimen.
Recognizes tenascin, a large hexameric extracellular matrix glycoprotein
Immunohistochemistry (paraffin sections): Application note - Immunohistochemical detection of tenascin is valuable for studies of tissue differentiation and tumour growth. The antibody T2H5 is excellent for staining of paraffin-embedded tissue sections.
PBS, 15 mM sodium azide, approx., pH 7.4.
+4°C or -20°C, Avoid repeated freezing and thawing.
Tenascin C (TNC) is the founding member of the gene family. In the embryo it is made by migrating cells like the neural crest; it is also abundant in developing tendons, bone and cartilage. The basic structure is 14 EGF-like repeats towards the N-terminal end, and 8 or more fibronectin-III domains which vary upon species and variant. TNC has anti-adhesive properties, causing cells in tissue culture to become rounded after it is added to the medium.