Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Human (tested or 100% immunogen sequence identity)
Western blot (1:500 - 1:3000)
Specificity and Use
TMEM67 antibody was raised against recombinant fragment corresponding to a region within amino acids 231 and 510 of meckelin isoform 1 (SwissProt Q5HYA8). Percent identity by BLAST analysis: Human (100%); Bovine (88%); Mouse (82%); Rat (81%).
0.1 M Tris-glycine, pH 7.0, 10% glycerol, 0.01% Thimerosal
Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
TMEM67 Antibody, JBTS6 Antibody, NPHP11 Antibody, Meckel syndrome type 3 protein Antibody, MKS3 Antibody, Transmembrane protein 67 Antibody, TNEM67 Antibody, Meckel syndrome, type 3 Antibody, Meckelin Antibody
Required for ciliary structure and function. Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition (By similarity). Involved in centrosome migration to the apical cell surface during early ciliogenesis. Involved in the regulation of cilia length and appropriate number through the control of centrosome duplication. Required for cell branching morphology.