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Anti-TLR4 Antibody LS-C10733

Ordering

Wt. Vol. Conc. Price
100 µg - - $605
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
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Rat Monoclonal (IgG2a) to Mouse TLR4
Mouse
Immunoprecipitation, Flow Cytometry
Unconjugated

Details

Mouse TLR4
Rat
Mouse (tested or 100% immunogen sequence identity)
IgG2a Monoclonal
Purified

Applications

Immunoprecipitation, Flow Cytometry (1:10)

Specificity and Use

Reacts preferentially, especially in flow cytometry, with mouse TLR4 that is associated with MD-2. Recognizes the mouse TLR4/MD-2 complex and is not useful for detection of TLR4 alone.
Can be used for Flow Cytometry and Immunoprecipitation. The antibody recognizes the mouse TLR4/MD-2 complex and is not useful for detection of TLR4 alone. Furthermore the antibody can be used as antagonist for TLR4, it blocks LPS-induced cytokine production. Flow Cytometry: 1:10. Before use in biological assays, the product must be filter sterilized and depending on the concentration to be used dialyzed against culture medium to remove the sodium azide added. Please inquire for availability of azide free solutions.

Packaging

PBS, 0.02% sodium azide, 0.1% BSA.
Long term: Add glycerol (40-50%) -20°C; Short term: +4°C
For research use only.

About TLR4

O00206 NM_138554 O00206

TLR4 Antibody, CD284 Antibody, CD284 antigen Antibody, Homolog of Drosophila toll Antibody, TLR-4 Antibody, TOLL Antibody, ARMD10 Antibody, Toll-like receptor 4 Antibody, HToll Antibody

Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate, and Ni2+. Responses triggered by Ni2+ require non-conserved histidines and are, therefore, species-specific.

Requested From: United States
Date Requested: 9/29/2016

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