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The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described.
Gene Name: | toll-interleukin 1 receptor (TIR) domain containing adaptor protein |
Synonyms: | TIRAP, Adapter protein wyatt, BACTS1, Adaptor protein Wyatt, MyD88 adapter-like protein, Wyatt |
Target Sequences: | NM_148910 AAP31973.1 P58753 |
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