Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse, Human (tested or 100% immunogen sequence identity)
Western blot (1 - 10 µg/ml)
ELISA (1:10000 - 1:100000)
Specificity and Use
TIMELESS antibody was raised against a mixture of 14aa peptide sequence near the N-terminus of mouse Tim1 and 14aa peptide sequence from the C-terminus of human Tim1 (KLH coupled).
Recognizes mouse and human (Tim1). Species sequence Homology (Mouse Tim1 peptide): Rat (100%), Drosophila (85%), Human (85%). Species sequence Homology (Human Tim1 peptide): Mouse (57%). Expected to cross-react with rat and Drosophila based on sequence homology.
Suitable for use in ELISA and Western Blot. Western Blot: 1-10 ug/ml using ECL.
Plays an important role in the control of DNA replication, maintenance of replication fork stability, maintenance of genome stability throughout normal DNA replication and in the regulation of the circadian clock. Involved in the determination of period length and in the DNA damage-dependent phase advancing of the circadian clock. Negatively regulates CLOCK|NPAS2-ARTNL/BMAL1|ARTNL2/BMAL2-induced transactivation of PER1 possibly via translocation of PER1 into the nucleus.