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Anti-TIMD4 / TIM4 / TIM-4 Antibody (clone RMT4-54, Low Endotoxin) LS-C187578

Ordering

Wt. Vol. Conc. Price
500 µg - 1 mg/ml $450
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
Orders@LSBio.com
 

Most Popular TIMD4 / TIM4 / TIM-4 Antibodies

Anti-TIMD4 / TIM4 / TIM-4 Antibody (C-Terminus) IHC-plus™ LS-B598
Rabbit Polyclonal to Human TIMD4 / TIM4 / TIM-4
Human, Mouse, Rat
IHC - Paraffin, Western blot
Unconjugated
Immunohistochemistry Image
Anti-TIMD4 / TIM4 / TIM-4 Antibody (Internal) IHC-plus™ LS-B1413
Rabbit Polyclonal to Human TIMD4 / TIM4 / TIM-4
Human, Mouse
IHC - Paraffin, IHC - Frozen, ICC, Immunofluorescence, Western blot
Unconjugated
Immunohistochemistry Image
Anti-TIMD4 / TIM4 / TIM-4 Antibody (clone RMT4-54) LS-C187579
Rat Monoclonal [clone RMT4-54] (IgG2a) to Mouse TIMD4 / TIM4 / TIM-4
Mouse
IHC - Paraffin, Immunofluorescence, Flow Cytometry
Unconjugated
Flow Cytometry Image

100% Guaranteed 100% Guaranteed
Rat Monoclonal [clone RMT4-54] (IgG2a) to Mouse TIMD4 / TIM4 / TIM-4
Mouse
IHC - Paraffin, Immunofluorescence, Flow Cytometry, Functional Assay (applications tested for the base form of this product only)
Unconjugated, Low Endotoxin

Details

Mouse TIMD4 / TIM4 / TIM-4
Rat
Mouse (tested or 100% immunogen sequence identity)
IgG2a Monoclonal [RMT4-54]
Unconjugated
Protein G purified
Low Endotoxin. Also available Unmodified.

Applications

  • IHC - Paraffin
  • Immunofluorescence
  • Flow Cytometry
  • Functional Assay
  • (applications tested for the base form of this product only)

Specificity and Use

TIMD4 / TIM4 / TIM-4 antibody was raised against tim-4-Ig, consisting of amino acids 1-288 of mouse Tim-4, coupled with the Fc portion of mouse IgG2a.
Clone RMT4-54 specifically recognizes mouse Tim-4 (T-cell immunoglobulin mucin 4), a transmembrane glycoprotein and member of the immunoglobulin superfamily, exclusively expressed by antigen-presenting cells, which acts as the natural ligand of Tim-1, involved in T-cell expansion and cytokine production. Tim-4 is reported to be crucial for the phagocytosis of apoptotic cells by peritoneal macrophages, and studies have shown that interaction between Tim-1 on Th2 cells and Tim-4 on DCs, enhances Th2 cell function. The TIM-4 gene locus is associated with predisposition to asthma in both mice and humans and may be considered as a candidate disease gene for asthma. Studies have shown that clone RMT4-54 significantly inhibits the efficient phagocytosis of apoptotic cells by PRMs (peritoneal resident Mac1+ cells), but not PEMs (peritoneal exudate Mac1+ cells) see for details.
The applications listed have been tested for the unmodified form of this product. Other forms have not been tested.

Packaging

PBS
Store at -20°C. Minimize freezing and thawing.
For research use only.

About TIMD4 / TIM4 / TIM-4

Q96H15 NM_138379 NP_612388.2

TIMD4 Antibody, SMUCKLER Antibody, TIM-4 Antibody, T-cell membrane protein 4 Antibody, TIM4 Antibody, TIMD-4 Antibody, TIM 4 Antibody

Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Involved in regulating T-cell proliferation and lymphotoxin signaling. Ligand for HAVCR1/TIMD1.

Flow Cytometry

Flow Cytometry
Mouse TIM-4 transfected NRK cells stained with Rat anti-Mouse TIM-4. This image was taken for the unmodified form of this product. Other forms have not been tested.
 

Requested From: United States
Date Requested: 12/8/2016

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