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Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix.
Gene Name: | tuftelin interacting protein 11 |
Synonyms: | TFIP11, BK445C9.6, DKFZP434B194, HNtr1, NTR1, Spp382, STIP, TIP39, STIP-1 |
Target Sequences: | NM_012143 NP_036275.1 Q9UBB9 |
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