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Anti-Tetanus Toxin Antibody (clone TetH6) LS-C58399

Ordering

Wt. Vol. Conc. Price
200 µg - 1 mg/ml $365
Inquire for larger quantities

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Most Popular Tetanus Toxin Antibodies

Anti-Tetanus Toxin Antibody (clone TetH6) LS-C58399
Mouse Monoclonal [clone TetH6] (IgG1) to Clostridium tetani Tetanus Toxin
Clostridium tetani
Western blot, ELISA, Functional Assay
Unconjugated
Anti-Tetanus Toxin Antibody LS-C92716
Mouse Monoclonal (IgG1) to Clostridium tetani Tetanus Toxin
Clostridium tetani
Western blot, ELISA
Unconjugated
Anti-Tetanus Toxin Antibody LS-C92718
Mouse Monoclonal (IgG1) to Clostridium tetani Tetanus Toxin
Clostridium tetani
Western blot, ELISA
Unconjugated

100% Guaranteed 100% Guaranteed
Mouse Monoclonal [clone TetH6] (IgG1) to Clostridium tetani Tetanus Toxin
Clostridium tetani
Western blot, ELISA, Functional Assay
Unconjugated

Details

Clostridium tetani Tetanus Toxin
Mouse
Clostridium tetani (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [TetH6]
Unconjugated
Affinity purified
Unmodified

Applications

  • Western blot
  • ELISA
  • Functional Assay

Specificity and Use

Tetanus Toxin antibody was raised against supernatant from Clostridium tetani.
Recognizes the tetanus toxin, a neurotoxin produced by the vegetative spore of Clostridium tetani. The toxin causes tetanus, a disease that is characterized by prolonged contraction of skeletal muscle. World-wide, approximately 1 million cases of tetanus occurs annually, resulting in approximately 300000 to 500000 deaths, mostly in developing countries. The tetanus toxin has a molecular weight of approximately 150kD and consists of a heavy chain (B-chain, 100kD) and a light chain (A-chain, 50kD) that are connected by a disulfide bond. The toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits the release of the neurotransmitters GABA and glycine by synaptobrevin-2. This results in overactivity in the muscle. The binding of the toxin to neurons is irreversible. Has toxin neutralizing activity. Removal of sodium azide is recommended prior to use in functional assays.

Packaging

PBS, 0.09% sodium azide.
Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
For research use only.

About Tetanus Toxin

Tetanus toxin is an extremely potent neurotoxin produced by the vegetative cell of Clostridium tetani in anaerobic conditions, causing tetanus. It has no known function for clostridia in the soil environment where they are normally encountered. It is also called spasmogenic toxin, or TeNT. The LD50 of this toxin has been measured to be approximately 1 ng/kg, making it second only to Botulinum toxin as the deadliest toxin in the world.

Requested From: United States
Date Requested: 12/6/2016

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