Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
(applications tested for the base form of this product only)
Specificity and Use
TEK / TIE2 antibody was raised against the extracellular domain of mouse Tie2 receptor.
Recognizes mouse Tie2 Receptor.
Suitable for use in Flow Cytometry, ELISA, Western Blot and Immunoprecipitation. Western Blot: 5 ug/ml, detects 20 ng recombinant Tie-2. Recognizes a band at ~140kD. Flow Cytometry: 10 ug/ml. Immunoprecipitation: 10 ug/ml of lysate. Positive control: Placenta and lung tissue.
PBS, pH 7.4, 0.05% Bronidox as preservative.
Short term: 4°C. Long term: Store at -20°C. Avoid freeze-thaw cycles.
VEGFR1-positive macrophages facilitate liver repair and sinusoidal reconstruction after hepatic ischemia/reperfusion injury. Ohkubo H, Ito Y, Minamino T, Eshima K, Kojo K, Okizaki S, Hirata M, Shibuya M, Watanabe M, Majima M. PloS one. 2014 9:e105533. (WB, Flo; Mouse)[Full Text Article]
Vasculogenic and hematopoietic cellular progenitors are scattered within the prenatal mouse heart. Jankowska-Steifer E, Madej M, Niderla-Bielinska J, Ruminski S, Flaht-Zabost A, Czarnowska E, Gula G, Radomska-Lesniewska DM, Ratajska A. Histochemistry and cell biology. 2015 143:153-69. (WB; Mouse)[Full Text Article]
Tyrosine-protein kinase that acts as cell-surface receptor for ANGPT1, ANGPT2 and ANGPT4 and regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Has anti-inflammatory effects by preventing the leakage of proinflammatory plasma proteins and leukocytes from blood vessels. Required for normal angiogenesis and heart development during embryogenesis.