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Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.
Gene Name: | transcription elongation factor A (SII), 3 |
Synonyms: | TCEA3, TFIISH, TFIIS.H, TFIIS |
Target Sequences: | NM_003196 NP_003187.1 O75764 |
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