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TBR1 is a member of a conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. A similar protein has been disrupted in mice and shown to be critical for early cortical development, and causes loss of projection neurons in the olfactory bulbs and olfactory cortex. The C-terminal region this similar protein was found to be necessary and sufficient for association with the guanylate kinase domain of calcium/calmodulin-dependent serine protein kinase.
Gene Name: | T-box, brain, 1 |
Synonyms: | TBR1, TBR-1, T-box brain protein 1, T-brain-1, T-box, brain, 1, TES-56 |
Target Sequences: | NM_006593 NP_006584.1 Q16650 |
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