Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Synaptophysin (Syn1) is an abundant synaptic vesicle membrane protein that contains four transmembrane regions. It forms a high molecular weight complex in the vesicle membrane containing at least four Syn I subunits and an 18 kD protein termed synaptobrevin/VAMP. Syn I is phosphorylated by both serine/threonine and tyrosine kinases on its cytoplasmic tail. Knockout studies in mice have shown that it is not essential for neurotransmitter release.
IHC of paraffin-embedded Human pancreas tissue using anti-SYP mouse monoclonal antibody.
Anti-SYP mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY SYP.
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY SYP (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-SYP.