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Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching and the regulation of neurite length. Required for normal synaptic vesicle endocytosis; this process retrieves previously released neurotransmitters to accommodate multiple cycles of neurotransmission. Required for normal excitatory and inhibitory synaptic transmission By similarity. Binds to membranes via its F-BAR domain and mediates membrane tubulation.
Gene Name: | protein kinase C and casein kinase substrate in neurons 1 |
Synonyms: | PACSIN1, KIAA1379, Syndapin I, SDPI |
Target Sequences: | AB037800 BAA92617.2 Q9BY11 |
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