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SUV39H2

suppressor of variegation 3-9 homolog 2 (Drosophila)

Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher-order chromatin organization during spermatogenesis. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation.

Gene Name: suppressor of variegation 3-9 homolog 2 (Drosophila)
Synonyms: SUV39H2, H3-K9-HMTase 2, Lysine N-methyltransferase 1B, Su(var)3-9 homolog 2, KMT1B
Target Sequences: AK027067 BAB15645.1 Q9H5I1

Publications (4)

1
Major satellite repeat RNA stabilize heterochromatin retention of Suv39h enzymes by RNA-nucleosome association and RNA:DNA hybrid formation. Velazquez Camacho O, Galan C, Swist-Rosowska K, Ching R, Gamalinda M, Karabiber F, De La Rosa-Velazquez I, Engist B, Koschorz B, Shukeir N, Onishi-Seebacher M, van de Nobelen S, Jenuwein T. eLife. 2017 6: (WB; Mouse) [Full Text Article] [PubMed:28760199] [PMC:PMC5538826] Related Antibodies: LS-C116360.
2
Complete loss of H3K9 methylation dissolves mouse heterochromatin organization. Thomas Montavon, Nicholas Shukeir, Galina Erikson, Bettina Engist, Megumi Onishi-Seebacher, Devon Ryan, Yaarub Musa, Gerhard Mittler, Alexandra Graff Meyer, Christel Genoud, Thomas Jenuwein. Nature communications. 2021 July;12:4359. [Full Text Article] [PubMed:34272378] [PMC:PMC8285382] Related Antibodies: LS-C116360.
3
Regulation of mammalian 3D genome organization and histone H3K9 dimethylation by H3K9 methyltransferases. Kei Fukuda, Chikako Shimura, Hisashi Miura, Akie Tanigawa, Takehiro Suzuki, Naoshi Dohmae, Ichiro Hiratani, Yoichi Shinkai. Communications biology. 2021 May;4:571. [Full Text Article] [PubMed:33986449] [PMC:PMC8119675] Related Antibodies: LS-C116360.
4
HP1 maintains protein stability of H3K9 methyltransferases and demethylases. Ryo Maeda, Makoto Tachibana. EMBO reports. 2022 April;23:e53581. [Full Text Article] [PubMed:35166421] [PMC:PMC8982598] Related Antibodies: LS-C116360.
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☰ Filters
Antibodies (37)
Proteins (3)
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SUV39H2 (40)
Human (37)
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rabbit (36)
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aa360-390 (7)
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SUV39H2 Antibody - SUV39H2 antibody Western blot of HepG2 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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SUV39H2 Rabbit anti-Human Polyclonal (aa287-336) Antibody
Human
WB
Unconjugated
100 µl/$424
SUV39H2 Antibody - Immunohistochemistry of paraffin-embedded human breast cancer using antibody at 1:100 dilution.
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SUV39H2 Rabbit anti-Human Polyclonal (aa201-410) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$294; 100 µl/$360
SUV39H2 Antibody - Western blot analysis of extracts of various cell lines, using SUV39H2 antibody.
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SUV39H2 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ChIP-Seq, ChrIP, IHC, IP, WB
Unconjugated
20 µl/$275; 100 µl/$389
SUV39H2 Antibody - Staining 293T cells by IF/ICC. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 min at 25°C. The primary antibody was diluted at 1:200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibody.
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SUV39H2 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
SUV39H2 Antibody - Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
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SUV39H2 Rabbit anti-Human Polyclonal (aa360-390) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
SUV39H2 Antibody - Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
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SUV39H2 Rabbit anti-Human Polyclonal (aa93-122) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
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SUV39H2 Rabbit anti-Human Polyclonal (aa360-390) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
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SUV39H2 Rabbit anti-Human Polyclonal (aa360-390) (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
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SUV39H2 Rabbit anti-Human Polyclonal (aa360-390) (FITC) Antibody
Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
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SUV39H2 Rabbit anti-Human Polyclonal (aa360-390) (APC) Antibody
Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
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SUV39H2 Rabbit anti-Human Polyclonal (aa360-390) (PE) Antibody
Human
ELISA, IHC, WB
PE Conjugated
200 µl/$952
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SUV39H2 Rabbit anti-Human Polyclonal (aa360-390) (Azide-free) (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
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SUV39H2 Rabbit anti-Human Polyclonal (aa93-122) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
Select
SUV39H2 Rabbit anti-Human Polyclonal (aa93-122) (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
Select
SUV39H2 Rabbit anti-Human Polyclonal (aa93-122) (FITC) Antibody
Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
Select
SUV39H2 Rabbit anti-Human Polyclonal (aa93-122) (APC) Antibody
Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
Select
SUV39H2 Rabbit anti-Human Polyclonal (aa93-122) (Azide-free) (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
Select
SUV39H2 Rabbit anti-Human Polyclonal (aa93-122) (PE) Antibody
Human
ELISA, IHC, WB
PE Conjugated
200 µl/$952
SUV39H2 Antibody - Immunohistochemistry of paraffin-embedded Human prost at e cancer tissue  using SUV39H2 Polyclonal Antibody at dilution of 1:70(×200)
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SUV39H2 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
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SUV39H2 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
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SUV39H2 Rabbit anti-Human Polyclonal (aa367-395) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
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SUV39H2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$341
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SUV39H2 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, WB
Unconjugated
100 µg/$357
SUV39H2 Antibody - Western blot of KMT1B antibody
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SUV39H2 Rabbit anti-Human Polyclonal (80-160 aa, Internal) Antibody
Mouse, Human
ELISA, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
SUV39H2 Antibody - Western blot analysis of the lysates from 293 cells using SUV39H2 antibody.
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SUV39H2 Rabbit anti-Human Polyclonal (aa101-150) Antibody
Mouse, Human
Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
Viewing 1-25 of 40 product results



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).