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Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of estradiol and estrone. May play a role in the regulation of estrogen receptor activity by metabolizing free estradiol. Maximally sulfates beta-estradiol and estrone at concentrations of 20 nM. Also sulfates dehydroepiandrosterone, pregnenolone, ethinylestradiol, equalenin, diethylstilbesterol and 1-naphthol, at significantly higher concentrations; however, cortisol, testosterone and dopamine are not sulfated.
Gene Name: | Sulfotransferase Family 1E, Estrogen-preferring, Member 1 |
Synonyms: | SULT1E1, Estrogen sulfotransferase, EST, EST-1, ST1E1, STE, Sulfotransferase 1E1 |
Target Sequences: | NM_005420 NP_005411.1 P49888 |
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