Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Staphylococcus, E. coli, Mycoplasma, Streptococcus
Mouse Monoclonal [clone SEG-16] (IgG2a) to Staphylococcus aureus
Western blot, ELISA
Staphylococcus aureus (tested or 100% immunogen sequence identity)
IgG2a Monoclonal [SEG-16]
Specificity and Use
Staphylococcus aureus Enterotoxin type G.
Recognizes Staphylococcus aureus enterotoxin type G. Staphylococcus aureus produces several different types of enterotoxins (SE's). The SE's are short, soluble proteins that are highly stable and resistant to most proteolytic enzymes. They belong to a family of pyrogenic toxins and as such cause an increase in body temperature, immunosuppression and non-specific T-cell proliferation. These activities are referred to as superantigen activity and results from the interaction of SE's with T-cell antigen receptors and the major histocompatibility complex (MHC) on antigen presenting cells. In addition to their superantigen activity, SE's are also emetics (they cause vomiting). The SE's are important in food poisoning. Enterotoxin G is implicated in scarlet fever, toxic shock and bovine mastitis. May be used to detect S. aureus enterotoxin G in ELISA assays.